Gene Expression Literature Summary

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Hoxd13  homeobox D13   (Synonyms: Hox-4.8, spdh)
Results	Reference
1*	J:49264 Beckers J, Duboule D, Genetic analysis of a conserved sequence in the HoxD complex: regulatory redundancy or limitations of the transgenic approach?. Dev Dyn. 1998 Sep;213(1):1-11
1	J:144933 Benazet JD, Bischofberger M, Tiecke E, Goncalves A, Martin JF, Zuniga A, Naef F, Zeller R, A self-regulatory system of interlinked signaling feedback loops controls mouse limb patterning. Science. 2009 Feb 20;323(5917):1050-3
1	J:159210 Galli A, Robay D, Osterwalder M, Bao X, Benazet JD, Tariq M, Paro R, Mackem S, Zeller R, Distinct roles of Hand2 in initiating polarity and posterior Shh expression during the onset of mouse limb bud development. PLoS Genet. 2010;6(4):e1000901
1*	J:30345 Haramis AG, Brown JM, Zeller R, The limb deformity mutation disrupts the SHH/FGF-4 feedback loop and regulation of 5' HoxD genes during limb pattern formation. Development. 1995 Dec;121(12):4237-45
1	J:253972 Hwang SH, White KA, Somatilaka BN, Shelton JM, Richardson JA, Mukhopadhyay S, The G protein-coupled receptor Gpr161 regulates forelimb formation, limb patterning and skeletal morphogenesis in a primary cilium-dependent manner. Development. 2018 Jan 8;145(1):dev154054
1	J:232412 Jeon S, Seong RH, Anteroposterior Limb Skeletal Patterning Requires the Bifunctional Action of SWI/SNF Chromatin Remodeling Complex in Hedgehog Pathway. PLoS Genet. 2016 Mar;12(3):e1005915
1	J:69771 Lewis PM, Dunn MP, McMahon JA, Logan M, Martin JF, St-Jacques B, McMahon AP, Cholesterol modification of sonic hedgehog is required for long-range signaling activity and effective modulation of signaling by Ptc1. Cell. 2001 Jun 1;105(5):599-612
1	J:213641 Lopez-Rios J, Duchesne A, Speziale D, Andrey G, Peterson KA, Germann P, Unal E, Liu J, Floriot S, Barbey S, Gallard Y, Muller-Gerbl M, Courtney AD, Klopp C, Rodriguez S, Ivanek R, Beisel C, Wicking C, Iber D, Robert B, McMahon AP, Duboule D, Zeller R, Attenuated sensing of SHH by Ptch1 underlies evolution of bovine limbs. Nature. 2014 Jul 3;511(7507):46-51
1	J:30056 Luo G, Hofmann C, Bronckers AL, Sohocki M, Bradley A, Karsenty G, BMP-7 is an inducer of nephrogenesis, and is also required for eye development and skeletal patterning. Genes Dev. 1995 Nov 15;9(22):2808-20
1	J:74219 Ogino Y, Suzuki K, Haraguchi R, Satoh Y, Dolle P, Yamada G, External genitalia formation: role of fibroblast growth factor, retinoic acid signaling, and distal urethral epithelium. Ann N Y Acad Sci. 2001 Dec;948:13-31
1	J:49154 Partanen J, Schwartz L, Rossant J, Opposite phenotypes of hypomorphic and Y766 phosphorylation site mutations reveal a function for Fgfr1 in anteroposterior patterning of mouse embryos. Genes Dev. 1998 Aug 1;12(15):2332-44
1	J:147584 Patterson VL, Damrau C, Paudyal A, Reeve B, Grimes DT, Stewart ME, Williams DJ, Siggers P, Greenfield A, Murdoch JN, Mouse hitchhiker mutants have spina bifida, dorso-ventral patterning defects and polydactyly: identification of Tulp3 as a novel negative regulator of the Sonic hedgehog pathway. Hum Mol Genet. 2009 May 15;18(10):1719-39
1*	J:43311 Peichel CL, Prabhakaran B, Vogt TF, The mouse Ulnaless mutation deregulates posterior HoxD gene expression and alters appendicular patterning. Development. 1997 Sep;124(18):3481-92
1	J:43769 Qu S, Niswender KD, Ji Q, van der Meer R, Keeney D, Magnuson MA , Wisdom R, Polydactyly and ectopic ZPA formation in Alx-4 mutant mice. Development. 1997 Oct;124(20):3999-4008
1	J:57316 Sidow A, Bulotsky MS, Kerrebrock AW, Birren BW, Altshuler D, Jaenisch R, Johnson KR, Lander ES, A novel member of the F-box/WD40 gene family, encoding dactylin, is disrupted in the mouse dactylaplasia mutant. Nat Genet. 1999 Sep;23(1):104-7
1	J:169050 Soshnikova N, Montavon T, Leleu M, Galjart N, Duboule D, Functional analysis of CTCF during mammalian limb development. Dev Cell. 2010 Dec 14;19(6):819-30
1	J:79710 te Welscher P, Zuniga A, Kuijper S, Drenth T, Goedemans HJ, Meijlink F, Zeller R, Progression of vertebrate limb development through SHH-mediated counteraction of GLI3. Science. 2002 Oct 25;298(5594):827-30
1	J:317370 Trofka A, Huang BL, Zhu J, Heinz WF, Magidson V, Shibata Y, Shi YB, Tarchini B, Stadler HS, Kabangu M, Al Haj Baddar NW, Voss SR, Mackem S, Genetic basis for an evolutionary shift from ancestral preaxial to postaxial limb polarity in non-urodele vertebrates. Curr Biol. 2021 Nov 22;31(22):4923-4934.e5
1	J:330212 Wang S, Tanaka Y, Xu Y, Takeda S, Hirokawa N, KIF3B promotes a PI3K signaling gradient causing changes in a Shh protein gradient and suppressing polydactyly in mice. Dev Cell. 2022 Oct 10;57(19):2273-2289.e11
1	J:56002 Xu X, Weinstein M, Li C, Deng C, Fibroblast growth factor receptors (FGFRs) and their roles in limb development. Cell Tissue Res. 1999 Apr;296(1):33-43
1	J:89029 Yashiro K, Zhao X, Uehara M, Yamashita K, Nishijima M, Nishino J, Saijoh Y, Sakai Y, Hamada H, Regulation of retinoic acid distribution is required for proximodistal patterning and outgrowth of the developing mouse limb. Dev Cell. 2004 Mar;6(3):411-22
1	J:91567 Zakany J, Kmita M, Duboule D, A dual role for Hox genes in limb anterior-posterior asymmetry. Science. 2004 Jun 11;304(5677):1669-72
1	J:83305 Zhang Q, Murcia NS, Chittenden LR, Richards WG, Michaud EJ, Woychik RP, Yoder BK, Loss of the Tg737 protein results in skeletal patterning defects. Dev Dyn. 2003 May;227(1):78-90
1	J:149477 Zhang Z, Verheyden JM, Hassell JA, Sun X, FGF-regulated Etv genes are essential for repressing Shh expression in mouse limb buds. Dev Cell. 2009 Apr;16(4):607-13
1*	J:49322 Zuniga A, Zeller R, Gli3 (Xt) and formin (ld) participate in the positioning of the polarising region and control of posterior limb-bud identity. Development. 1999 Jan;126(1):13-21